A review of sleep-promoting medications used in pregnancy.
Identifieur interne : 000651 ( Main/Exploration ); précédent : 000650; suivant : 000652A review of sleep-promoting medications used in pregnancy.
Auteurs : Michele L. Okun [États-Unis] ; Rebecca Ebert [États-Unis] ; Bandana Saini [Australie]Source :
- American journal of obstetrics and gynecology [ 1097-6868 ] ; 2015.
Descripteurs français
- KwdFr :
- Complications de la grossesse (traitement médicamenteux), Femelle, Grossesse, Humains, Hypnotiques et sédatifs (effets indésirables), Hypnotiques et sédatifs (usage thérapeutique), Malformations dues aux médicaments et aux drogues (étiologie), Naissance prématurée (), Nourrisson petit pour son âge gestationnel, Nourrisson à faible poids de naissance, Nouveau-né, Troubles de l'endormissement et du maintien du sommeil (traitement médicamenteux).
- MESH :
- effets indésirables : Hypnotiques et sédatifs.
- traitement médicamenteux : Complications de la grossesse, Troubles de l'endormissement et du maintien du sommeil.
- usage thérapeutique : Hypnotiques et sédatifs.
- étiologie : Malformations dues aux médicaments et aux drogues.
- Femelle, Grossesse, Humains, Naissance prématurée, Nourrisson petit pour son âge gestationnel, Nourrisson à faible poids de naissance, Nouveau-né.
English descriptors
- KwdEn :
- Abnormalities, Drug-Induced (etiology), Female, Humans, Hypnotics and Sedatives (adverse effects), Hypnotics and Sedatives (therapeutic use), Infant, Low Birth Weight, Infant, Newborn, Infant, Small for Gestational Age, Pregnancy, Pregnancy Complications (drug therapy), Premature Birth (chemically induced), Sleep Initiation and Maintenance Disorders (drug therapy).
- MESH :
- chemical , adverse effects : Hypnotics and Sedatives.
- chemically induced : Premature Birth.
- drug therapy : Pregnancy Complications, Sleep Initiation and Maintenance Disorders.
- etiology : Abnormalities, Drug-Induced.
- chemical , therapeutic use : Hypnotics and Sedatives.
- Female, Humans, Infant, Low Birth Weight, Infant, Newborn, Infant, Small for Gestational Age, Pregnancy.
Abstract
Approximately 4% of adults who have symptoms of insomnia resort to various hypnotic or sedating medications for acute symptom relief. Although typically a common practice for nonpregnant adults, this is not the case for the thousands of pregnant women who also report substantial sleep issues. Unfortunately, a paucity of randomized controlled trials in this population, scant empiric evidence regarding the appropriateness of prescribing options, and the concern of subsequent teratogenicity restricts the ability of clinicians to make informed decisions. We synthesized the current research regarding hypnotics and sedating medications used (both on- and off-label) during pregnancy and their association with adverse outcomes. Medications that we investigated included benzodiazepines, hypnotic benzodiazepine receptor agonists, antidepressants, and antihistamines. Overall, the examined studies showed no correlation of increased risk of congenital malformations. However, benzodiazepines and hypnotic benzodiazepine receptor agonists may increase rates of preterm birth, low birthweight, and/or small-for-gestational-age infants. The small number of studies and the small number of subjects prohibit any definitive interpretation regarding the consequences of the use of hypnotic or sedating medications in pregnancy. Additional case reports, randomized clinical trials, and epidemiologic studies are needed urgently.
DOI: 10.1016/j.ajog.2014.10.1106
PubMed: 25448509
Affiliations:
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Okun</name><affiliation wicri:level="2"><nlm:affiliation>University of Pittsburgh, Pittsburgh, PA; University of Colorado at Colorado Springs, Colorado Springs, CO. 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Although typically a common practice for nonpregnant adults, this is not the case for the thousands of pregnant women who also report substantial sleep issues. Unfortunately, a paucity of randomized controlled trials in this population, scant empiric evidence regarding the appropriateness of prescribing options, and the concern of subsequent teratogenicity restricts the ability of clinicians to make informed decisions. We synthesized the current research regarding hypnotics and sedating medications used (both on- and off-label) during pregnancy and their association with adverse outcomes. Medications that we investigated included benzodiazepines, hypnotic benzodiazepine receptor agonists, antidepressants, and antihistamines. Overall, the examined studies showed no correlation of increased risk of congenital malformations. However, benzodiazepines and hypnotic benzodiazepine receptor agonists may increase rates of preterm birth, low birthweight, and/or small-for-gestational-age infants. The small number of studies and the small number of subjects prohibit any definitive interpretation regarding the consequences of the use of hypnotic or sedating medications in pregnancy. Additional case reports, randomized clinical trials, and epidemiologic studies are needed urgently.</div></front></TEI><affiliations><list><country><li>Australie</li><li>États-Unis</li></country><region><li>Colorado</li><li>Nouvelle-Galles du Sud</li><li>Pennsylvanie</li></region><settlement><li>Sydney</li></settlement></list><tree><country name="États-Unis"><region name="Colorado"><name sortKey="Okun, Michele L" sort="Okun, Michele L" uniqKey="Okun M" first="Michele L" last="Okun">Michele L. Okun</name></region><name sortKey="Ebert, Rebecca" sort="Ebert, Rebecca" uniqKey="Ebert R" first="Rebecca" last="Ebert">Rebecca Ebert</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Saini, Bandana" sort="Saini, Bandana" uniqKey="Saini B" first="Bandana" last="Saini">Bandana Saini</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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